Peroxynitrite inhibits glutathione S-conjugate transport
نویسندگان
چکیده
منابع مشابه
Hepatic glutathione and glutathione S-conjugate transport mechanisms.
Glutathione (GSH) plays a critical role in many cellular processes, including the metabolism and detoxification of oxidants, metals, and other reactive electrophilic compounds of both endogenous and exogenous origin. Because the liver is a major site of GSH and glutathione S-conjugate biosynthesis and export, significant effort has been devoted to characterizing liver cell sinusoidal and canali...
متن کاملActivation of microsomal glutathione s-transferase by peroxynitrite.
Peroxynitrite (ONOO-) toxicity is associated with protein oxidation and/or tyrosine nitration, usually resulting in inhibition of enzyme activity. We examined the effect of ONOO- on the activity of purified rat liver microsomal glutathione S-transferase (GST) and found that the activity of reduced glutathione (GSH)-free enzyme was increased 4- to 5-fold by 2 mM ONOO-; only 15% of this increased...
متن کامل1-Chloro-2,4-Dinitrobenzene-Elicited Increase in Vacuolar Glutathione-S-Conjugate Transport Activity.
Unlike most other characterized organic solute transport in plants, uptake of the model compound S-(2,4-dinitrophenyl)glutathione (DNP-GS) and related glutathione-S-conjugated by vacuolar membranes is directly energized by MgATP. Here we show that exogenous application of the DNP-GS precursor 1-chloro-2,4-dinitrobenzene (CDNB) to seedlings of Vigna radiata (mung bean) increases the capacity of ...
متن کاملTransport of Oxidized Glutathione into Barley Vacuoles: Evidence for the Involvement of the Glutathione-S-Conjugate ATPase
Roberto Tommasini, Enrico Martinoia, Erwin Grill, Karl-Josef Dietz*, and Nikolaus Amrhein Institut für Pflanzenwissenschaften, ETH Zürich, Sonneggstraße 5, CH-8092 Zürich, Switzerland * Julius-von-Sachs-Institut für Biowissenschaften, Mittlerer Dallenbergweg 64, D-97082 Würzburg, Bundesrepublik Deutschland Z. Naturforsch. 48c, 867-871 (1993); received August 23, 1993 Glutathione, Transport, Vac...
متن کاملRegulation of catalase: inhibition by peroxynitrite and reactivation by reduced glutathione and glutathione S-transferase.
The regulation of stable catalase from Aspergillus niger was investigated. The preincubation of catalase with peroxynitrite (PN) resulted in a significant decrease in the production of O2, while the subsequent incubation with reduced glutathione (GSH, 1mM) led to restoration of the enzymatic activity. Western blot analysis revealed not only the increased immunoreactivities of 3-nitrotyrosine an...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Biomembranes
سال: 1997
ISSN: 0005-2736
DOI: 10.1016/s0005-2736(96)00251-9